Research interest
  • Cytotoxic and genotoxic effects of inorganic and organic forms of arsenic on normal mammalian cells in culture (V79).
  • Effect of some natural polyphenols like green tea and black tea on modulation of these cytotoxic and genotoxic effects of arsenic in V79 cells.
  • Elucidation of the oxidative damage caused by arsenic and its mitigation by antioxidant effect of tea in V79 cells as well as in normal human lymphocytes.
  • Detailed mechanistic study of the pro-oxidant activity of arsenic and its counteraction with tea in Swiss albino model.
  • Role of tea in imparting enhanced repair activity both in in vitro and in vivo models.
  • Establishment of single cell gel electrophoresis (SCGE) or comet assay and fluorescence analysis of DNA unwinding (FADU) as biomarkers for DNA damage in a chronically arsenic affected population and role of another natural polyphenol, curcumin in reducing the genotoxic effect of arsenic.
  • Randomized field trial with black tea against inhibition of DNA repair in chronically arsenic affected skin lesions in West Bengal, India